Drug allergic rhinitis treatment in pregnancy


Distinguishing between allergic rhinitis and rhinitis in pregnancy and therefore choosing the allergic rhinitis treatment in pregnancy.

Pregnancy often causes hyperemia and edema of the nasal mucosa. About 1/3 of pregnant women have the symptoms of nasal congestion during pregnancy – is called pregnancy rhinitis. Pregnancy rhinitis doesn’t have other signs of respiratory infection and the unclear allergic causes. Patients can be constant nasal congestion and accompany with liquid nasal secretion. Nasal congestion can lead to breath by the mouth at night and reduce the quality of sleep.

Physiology of rhinitis in pregnancy doesn’t know clear. It is argued that the change of estrogen and progesterone concentration, although there is very little specific evidence.

Allergic rhinitis and rhinitis in pregnancy don’t affect directly to the fetus. However, if uncontrolled,  rhinitis may indirectly affect to the fetus by the impact of nutritional pregnancy, sleep and stress. In addition,  Several studies show that uncontrolled rhinitis can cause snoring. This can increase the risk of gestational hypertension, preeclampsia and retarded fetus in the uterus. Uncontrolled rhinitis can make heavier asthma accompany or lead to sinusitis during pregnancy.

allergic rhinitis treatment in pregnancy

Drugs for allergic rhinitis treatment in pregnancy

Glucocorticoid in nasal spray:

Glucocorticoid nasal has highly effective for allergic rhinitis and is considered as the suitable use for allergic rhinitis treatment in pregnancy. Pregnant women should use the lowest dose that it brings effective. There is no large difference in effectiveness or safety between the glucocorticoid form by nasal tract. Thus, if a patient has used any glucocorticoid products by nasal tract and is well controlled, the constant use of this product during pregnancy is reasonable.


Oral antihistamine has less effective to reduce nasal congestion and runny nose in the allergic rhinitis treatment in pregnancy compares with glucocorticoid by nasal tract. Several studies have evaluated the safety of antihistamine in pregnancy. Most pregnant women want to use the most appropriate antihistamine with the second generation as: acrivastin, cetirizin, loratadin, mizolastin and terfenadin… because this drug has less sedative effect. The anticholinergic side effect is lower than one generation (alimemazin, chlopheniramin, promethazin). Loratadin and cetirizin can be considered as the first choice in pregnancy. The safe data of this drug lies on a large amount of pregnant patient.

Antihistamine nasal spray: there is the safe data in people of Azelastine or olopatadine nasal spray. Although The studies in animal show that it is safe. Until having more information, you should avoid the use of this drug in pregnancy. Unless the patient respond with one of the two drugs before pregnancy.

allergic rhinitis treatment in pregnancy

Vasoconstrictor decongestant, reducing congestion:

Vasoconstrictor in here (Naphazoline, oxymetazoline, xylometazolin…): can use in a short time (under 3 days). It reduces the heavy state of nasal congestion. There are some data on the safety in people of oxymetazoline by nasal tract when using in the short-term during pregnancy. However, patients should be warned the abuse of drug if prolonged using.

Vasoconstrictor drug, oral decongestant: It is the best way to completely avoid using oral decongestant during the first 3 months of pregnancy due to the risk of uncertainty about a rare birth defect that these drugs cause. This is opening abdominal wall.

Antihistamine and decongestant combine: Patients with allergic rhinitis have the symptoms of  nasal congestion significantly. They report the reducing symptoms when the treatment combines  antihistamine and pseudoephedrine drug than using a separate drug. However, pseudoephedrine are advised to avoid using in the first 3 months of pregnancy.

The advice of the doctor

Pregnant women should be careful when using the drug. When there are the expressions of the disease should go to examine and take the drug by under dative guidance of the doctor  . Don’t absolutely  use the drug according to tell, because the drug can be safe with this person and cause dangerous to others. Especially, for pregnant women gets allergic. The use of the drug allergic rhinitis treatment in pregnancy need to pay attention because they are very sensitive body. The improperly use of the drug can happen unfortunate consequences, dangerous for both mother and child.

The article mentions the drug of allergic rhinitis treatment in pregnancy. Pregnant women should be careful these drugs. These drugs can affect directly to the fetus and cause dangerous the fetus’s health accompany with other complications. So if you get this disease, you should go to the hospital and your doctor find the drugs styles, which don’t affect to the fetus.